Global Cell-free Protein Expression Market - Segmented by Product (Accessories and Consumables, and Lysate Systems), By Application, By End User, and By Geography- Growth, Trends, and Forecast (2022 - 2030)

Market Overview

The cell-free protein expression market is expected to register a CAGR of 6.1% over the forecast period. Cell-free protein expression, or in vitro protein synthesis, is a process that involves the production of recombinant proteins in cell lysate solutions, without using cell culture or living cells. Cell-free protein expression can be carried out using different cell lysates, such as those of E. coli, rabbit reticulocytes, wheat germs, human cells, and insect cells. Increasing R&D in the field of proteomics and genomics and advantages offered by cell-free protein expression techniques, such as shorter expression time and structural modification, are contributing to the growth of the market. However, the lack of efficient systems for post-translational modifications and high costs could adversely affect market growth.

Advantages, such as Shorter Expression Time and Structural Modification, are Contributing to Market Growth

Cell-free protein expression system has significant advantages over living-cell-based protein expression, including shorter duration of the process, isotopic labeling of proteins, the incorporation of non-natural amino acids, optimization of protein complexes, and cost-effectiveness. Furthermore, these techniques enable the manufacture of proteins that are toxic to host cells in the recombinant techniques. In vitro techniques also enable the co-expression of multiple proteins, and can easily be employed for automation, making high-throughput production of therapeutic proteins possible.
Other factors which are contributing to the market growth include increasing R&D in the field of proteomics and genomics and high prevalence of cancer and infectious disease

Lack of Efficient Systems for Post-Translational Modifications Is Limiting Market Growth

Despite significant advances in in vitro protein expression techniques, the lack of cost-effective and efficient systems for post-translational modifications remains a significant hurdle for the growth of the global market. E. coli lysates remain most commonly utilized in vitro protein expression systems, owing to their high protein yield and tolerability to additives. However, many of the eukaryotic proteins synthesized using E. coli lysate become insoluble upon expression, and post-translational modifications are also not possible. The inability of high yield systems to perform post-translational modifications, and human-cell-based systems’ low production yield could inhibit market growth, over the forecast period.
Other factors that could potentially impede the growth of the market include high costs of cell-free protein expression kits.

North America Dominates the Cell-free Protein Expression Market

In 2017, North America was the largest regional market in terms of revenue. The increasing prevalence of chronic diseases such as cancer, aging population, growing demand for targeted and personalized medicine, the presence of major R&D facilities, and favorable government initiatives are major factors contributing to the large market size

Key Developments in the Cell-free Protein Expression Market

• Aug 2018: LenioBio GmbH and Fraunhofer IME announced an exclusive license agreement for Fraunhofer's proprietary vector solution for the cryopreservation of cell lysates, and LenioBio GmbH revealed plans to launch its expression kit under the brand name ALiCE.

Major Players: BIONEER CORPORATION, BIOTECHRABBIT GMBH, CELLFREE SCIENCES CO. LTD, CUBE BIOTECH GMBH, GENECOPOEIA INC., JENA BIOSCIENCE GMBH, NEW ENGLAND BIOLABS LTD, PROMEGA CORPORATION, QIAGEN NV, SIGMA-ALDRICH CORPORATION (MERCK KGAA), TAKARA BIO INC., and THERMO FISHER SCIENTIFIC INC., among others.

Reasons to Purchase Cell-free Protein Expression Market Report

• Analysis of various perspectives of the global cell-free protein expression market, with the help of Porter’s five forces analysis
• The segment that is expected to dominate the market
• Regions that are expected to witness fastest growth during the forecast period
• Identification of the latest developments, market shares, and strategies employed by the major market players
• 3-month analyst support, along with the Market Estimate sheet (in Excel)

Customization of the Cell-free Protein Expression Market Report

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