TABLE OF CONTENTS: 1 EXECUTIVE SUMMARY 2 MARKET INTRODUCTION 2.1 DEFINITION 15 2.2 SCOPE OF THE STUDY 15 2.3 ASSUMPTIONS & LIMITATIONS 15 2.3.1 ASSUMPTIONS 15 2.3.2 LIMITATIONS 15 2.4 MARKET STRUCTURE 16 3 RESEARCH METHODOLOGY 4 MARKET DYNAMICS 4.1 INTRODUCTION 26 4.2 DRIVERS 27 4.2.1 RISING AMNIOTIC MEMBRANE TRANSPLANTATIONS 27 4.2.2 RAPID GROWTH IN THE GERIATRIC POPULATION 27 4.2.3 INCREASING RESEARCH ACTIVITIES 28 4.3 RESTRAINTS 28 4.3.1 RISING HEALTHCARE COST 28 4.3.2 STRINGENT REGULATORY POLICIES 28 4.4 OPPORTUNITIES 29 4.4.1 ENTERING DEVELOPING ECONOMIES 29 4.4.2 INCREASING AWARENESS ABOUT THE ADVANTAGES OF AMNIOTIC MEMBRANE TRANSPLANT 29 5 MARKET FACTOR ANALYSIS 5.1 VALUE CHAIN ANALYSIS 30 5.1.1 R&D 30 5.1.2 MANUFACTURING 30 5.1.3 DISTRIBUTION & SALES 30 5.1.4 POST-SALES MONITORING 31 5.2 PORTER’S FIVE FORCES ANALYSIS 31 5.2.1 BARGAINING POWER OF SUPPLIERS 31 5.2.2 BARGAINING POWER OF BUYERS 32 5.2.3 THREAT OF NEW ENTRANTS 32 5.2.4 THREAT OF SUBSTITUTES 32 5.2.5 INTENSE RIVALRY 32 5.3 INVESTMENT OPPORTUNITIES 33 5.4 PRICING ANALYSIS 33 6 GLOBAL AMNIOTIC MEMBRANE MARKET, BY TYPE 6.1 OVERVIEW 34 6.2 CRYOPRESERVATION AMNIOTIC MEMBRANE 35 6.3 LYOPHILIZED AMNIOTIC MEMBRANE 36 7 GLOBAL AMNIOTIC MEMBRANE MARKET, BY APPLICATION 7.1 OVERVIEW 37 7.2 SURGICAL WOUNDS 38 7.3 OPHTHALMOLOGY 39 7.4 STEM CELL BIOLOGY 39 7.5 REGENERATIVE MEDICINE 40 7.6 PRENATAL DIAGNOSIS 41 7.7 OTHERS 41 8 GLOBAL AMNIOTIC MEMBRANE MARKET, BY END USER 8.1 OVERVIEW 42 8.2 HOSPITAL & CLINICS 43 8.3 AMBULATORY SURGICAL CENTERS 44 8.4 RESEARCH CENTERS AND LABORATORY 45 8.5 OTHERS 45 9 GLOBAL AMNIOTIC MEMBRANE MARKET, BY REGION 9.1 OVERVIEW 46 9.2 AMERICAS 48 9.2.1 NORTH AMERICA 50 9.2.2 LATIN AMERICA 54 9.3 EUROPE 55 9.3.1 WESTERN EUROPE 57 9.3.2 EASTERN EUROPE 65 9.4 ASIA-PACIFIC 67 9.4.1 JAPAN 69 9.4.2 CHINA 70 9.4.3 INDIA 71 9.4.4 SOUTH KOREA 72 9.4.5 AUSTRALIA 73 9.4.6 REST OF ASIA-PACIFIC 74 9.5 MIDDLE EAST & AFRICA 75 9.5.1 MIDDLE EAST 77 9.5.2 AFRICA 78 10 COMPETITIVE LANDSCAPE 10.1 INTRODUCTION 79 10.2 COMPANY SHARE ANALYSIS 79 11 COMPANY PROFILES 11.1 APPLIED BIOLOGICS 81 11.1.1 COMPANY OVERVIEW 81 11.1.2 FINANCIAL OVERVIEW 81 11.1.3 PRODUCTS/SERVICES OFFERED 81 11.1.4 KEY DEVELOPMENTS 81 11.1.5 SWOT ANALYSIS 81 11.1.6 KEY STRATEGIES 82 11.2 AQUAMED 83 11.2.1 COMPANY OVERVIEW 83 11.2.2 FINANCIAL OVERVIEW 83 11.2.3 PRODUCTS/SERVICES OFFERED 83 11.2.4 KEY DEVELOPMENTS 84 11.2.5 SWOT ANALYSIS 84 11.2.6 KEY STRATEGIES 84 11.3 INTEGRA LIFESCIENCES 85 11.3.1 COMPANY OVERVIEW 85 11.3.2 FINANCIAL OVERVIEW 85 11.3.3 PRODUCTS/SERVICES OFFERED 86 11.3.4 KEY DEVELOPMENTS 86 11.3.5 SWOT ANALYSIS 86 11.3.6 KEY STRATEGIES 87 11.4 SKYE BIOLOGICS INC. 88 11.4.1 COMPANY OVERVIEW 88 11.4.2 FINANCIAL OVERVIEW 88 11.4.3 PRODUCTS/SERVICES OFFERED 88 11.4.4 KEY DEVELOPMENTS 88 11.4.5 SWOT ANALYSIS 89 11.4.6 KEY STRATEGIES 89 11.5 MIMEDX 90 11.5.1 COMPANY OVERVIEW 90 11.5.2 FINANCIAL OVERVIEW 90 11.5.3 PRODUCTS/SERVICES OFFERED 90 11.5.4 KEY DEVELOPMENTS 91 11.5.5 SWOT ANALYSIS 91 11.5.6 KEY STRATEGIES 91 11.6 AMNIOX MEDICAL, INC. 92 11.6.1 COMPANY OVERVIEW 92 11.6.2 FINANCIAL OVERVIEW 92 11.6.3 PRODUCTS/SERVICES OFFERED 92 11.6.4 KEY DEVELOPMENTS 92 11.6.5 SWOT ANALYSIS 93 11.6.6 KEY STRATEGIES 93 11.7 KATENA PRODUCTS, INC. 94 11.7.1 COMPANY OVERVIEW 94 11.7.2 FINANCIAL OVERVIEW 94 11.7.3 PRODUCTS/SERVICES OFFERED 94 11.7.4 KEY DEVELOPMENTS 94 11.7.5 SWOT ANALYSIS 95 11.7.6 KEY STRATEGIES 95 11.8 HUMAN REGENERATIVE TECHNOLOGIES, LLC 96 11.8.1 COMPANY OVERVIEW 96 11.8.2 FINANCIAL OVERVIEW 96 11.8.3 PRODUCTS/SERVICES OFFERED 96 11.8.4 KEY DEVELOPMENTS 96 11.8.5 SWOT ANALYSIS 96 11.8.6 KEY STRATEGIES 96 11.9 AMNIO TECHNOLOGY, LLC 97 11.9.1 COMPANY OVERVIEW 97 11.9.2 FINANCIAL OVERVIEW 97 11.9.3 PRODUCTS/SERVICES OFFERED 97 11.9.4 KEY DEVELOPMENTS 97 11.9.5 SWOT ANALYSIS 97 11.9.6 KEY STRATEGIES 98 11.10 OSIRIS THERAPEUTICS, INC. 99 11.10.1 COMPANY OVERVIEW 99 11.10.2 FINANCIAL OVERVIEW 99 11.10.3 PRODUCTS/SERVICES OFFERED 99 11.10.4 KEY DEVELOPMENTS 100 11.10.5 SWOT ANALYSIS 100 11.10.6 KEY STRATEGIES 100 12 APPENDIX 12.1 REFERENCES 101 12.2 RELATED REPORTS 101

LIST OF TABLES: TABLE 1 GLOBAL AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 34 TABLE 2 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR CRYOPRESERVATION AMNIOTIC MEMBRANE, BY REGION, 2016–2025 (USD MILLION) 35 TABLE 3 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR LYOPHILIZED AMNIOTIC MEMBRANE, BY REGION, 2016–2025 (USD MILLION) 36 TABLE 4 GLOBAL AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 37 TABLE 5 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR SURGICAL WOUNDS, BY REGION, 2016–2025 (USD MILLION) 38 TABLE 6 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR OPHTHALMOLOGY, BY REGION, 2016–2025 (USD MILLION) 39 TABLE 7 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR STEM CELL BIOLOGY, BY REGION, 2016–2025 (USD MILLION) 39 TABLE 8 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR REGENERATIVE MEDICINE, BY REGION, 2016–2025 (USD MILLION) 40 TABLE 9 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR PRENATAL DIAGNOSIS, BY REGION, 2016–2025 (USD MILLION) 41 TABLE 10 GLOBAL AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 42 TABLE 11 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR HOSPITAL & CLINICS, BY REGION, 2016–2025 (USD MILLION) 43 TABLE 12 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR AMBULATORY SURGICAL CENTERS, BY REGION, 2016–2025 (USD MILLION) 44 TABLE 13 GLOBAL AMNIOTIC MEMBRANE MARKET, FOR RESEARCH CENTERS AND LABORATORY, BY REGION, 2016–2025 (USD MILLION) 45 TABLE 14 GLOBAL AMNIOTIC MEMBRANE MARKET, BY REGION, 2016–2025 (USD MILLION) 46 TABLE 15 AMERICAS: AMNIOTIC MEMBRANE MARKET, BY REGION, 2016–2025 (USD MILLION) 48 TABLE 16 AMERICAS: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 49 TABLE 17 AMERICAS: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 49 TABLE 18 AMERICAS: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 49 TABLE 19 NORTH AMERICA: AMNIOTIC MEMBRANE MARKET, BY COUNTRY, 2016–2025 (USD MILLION) 50 TABLE 20 NORTH AMERICA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 50 TABLE 21 NORTH AMERICA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 51 TABLE 22 NORTH AMERICA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 51 TABLE 23 US: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 52 TABLE 24 US: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 52 TABLE 25 US: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 52 TABLE 26 CANADA AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 53 TABLE 27 CANADA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 53 TABLE 28 CANADA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 53 TABLE 29 LATIN AMERICA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 54 TABLE 30 LATIN AMERICA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 54 TABLE 31 LATIN AMERICA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 54 TABLE 32 EUROPE: AMNIOTIC MEMBRANE MARKET, BY REGION, 2016–2025 (USD MILLION) 55 TABLE 33 EUROPE: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 56 TABLE 34 EUROPE: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 56 TABLE 35 EUROPE: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 57 TABLE 36 WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY COUNTRY, 2016–2025 (USD MILLION) 57 TABLE 37 WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 58 TABLE 38 WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 58 TABLE 39 WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 59 TABLE 40 GERMANY: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 59 TABLE 41 GERMANY: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 59 TABLE 42 GERMANY: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 60 TABLE 43 FRANCE: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 60 TABLE 44 FRANCE: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 60 TABLE 45 FRANCE: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 61 TABLE 46 UK: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 61 TABLE 47 UK: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 61 TABLE 48 UK: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 62 TABLE 49 ITALY: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 62 TABLE 50 ITALY: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 62 TABLE 51 ITALY: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 63 TABLE 52 SPAIN: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 63 TABLE 53 SPAIN: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 63 TABLE 54 SPAIN: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 64 TABLE 55 REST OF WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 64 TABLE 56 REST OF WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 64 TABLE 57 REST OF WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 65 TABLE 58 EASTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 65 TABLE 59 EASTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 65 TABLE 60 EASTERN EUROPE: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 66 TABLE 61 ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY COUNTRY, 2016–2025 (USD MILLION) 67 TABLE 62 ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 68 TABLE 63 ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 68 TABLE 64 ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 68 TABLE 65 JAPAN: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 69 TABLE 66 JAPAN: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 69 TABLE 67 JAPAN: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 69 TABLE 68 CHINA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 70 TABLE 69 CHINA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 70 TABLE 70 CHINA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 70 TABLE 71 INDIA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 71 TABLE 72 INDIA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 71 TABLE 73 INDIA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 71 TABLE 74 SOUTH KOREA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 72 TABLE 75 SOUTH KOREA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 72 TABLE 76 SOUTH KOREA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 72 TABLE 77 AUSTRALIA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 73 TABLE 78 AUSTRALIA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 73 TABLE 79 AUSTRALIA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 73 TABLE 80 REST OF ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 74 TABLE 81 REST OF ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 74 TABLE 82 REST OF ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 74 TABLE 83 MIDDLE EAST & AFRICA: AMNIOTIC MEMBRANE MARKET, BY REGION, 2016–2025 (USD MILLION) 75 TABLE 84 MIDDLE EAST & AFRICA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 76 TABLE 85 MIDDLE EAST & AFRICA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 76 TABLE 86 MIDDLE EAST & AFRICA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 76 TABLE 87 MIDDLE EAST: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 77 TABLE 88 MIDDLE EAST: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 77 TABLE 89 MIDDLE EAST: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 77 TABLE 90 AFRICA: AMNIOTIC MEMBRANE MARKET, BY TYPE, 2016–2025 (USD MILLION) 78 TABLE 91 AFRICA: AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2016–2025 (USD MILLION) 78 TABLE 92 AFRICA: AMNIOTIC MEMBRANE MARKET, BY END USER, 2016–2025 (USD MILLION) 78 LIST OF FIGURES: FIGURE 1 MARKET SYNOPSIS 14 FIGURE 2 GLOBAL AMNIOTIC MEMBRANE MARKET: MARKET STRUCTURE 16 FIGURE 3 BOTTOM-UP AND TOP-DOWN APPROACHES 23 FIGURE 4 VALUE CHAIN: GLOBAL AMNIOTIC MEMBRANE MARKET 30 FIGURE 5 PORTER’S FIVE FORCES ANALYSIS: GLOBAL AMNIOTIC MEMBRANE MARKET 31 FIGURE 6 GLOBAL AMNIOTIC MEMBRANE MARKET SHARE, BY TYPE, 2018 (%) 34 FIGURE 7 GLOBAL AMNIOTIC MEMBRANE MARKET, BY TYPE, 2018 & 2025 (USD MILLION) 35 FIGURE 8 GLOBAL AMNIOTIC MEMBRANE MARKET SHARE, BY APPLICATION, 2018 (%) 37 FIGURE 9 GLOBAL AMNIOTIC MEMBRANE MARKET, BY APPLICATION, 2018 & 2025 (USD MILLION) 38 FIGURE 10 GLOBAL AMNIOTIC MEMBRANE MARKET SHARE, BY END USER, 2018 (%) 42 FIGURE 11 GLOBAL AMNIOTIC MEMBRANE MARKET, BY END USER, 2018 & 2025 (USD MILLION) 43 FIGURE 12 GLOBAL AMNIOTIC MEMBRANE MARKET SHARE, BY REGION, 2018 (%) 47 FIGURE 13 GLOBAL AMNIOTIC MEMBRANE MARKET, BY REGION, 2018 & 2025 (USD MILLION) 47 FIGURE 14 AMERICAS: AMNIOTIC MEMBRANE MARKET SHARE, BY REGION, 2018 (%) 48 FIGURE 15 NORTH AMERICA: AMNIOTIC MEMBRANE MARKET SHARE, BY COUNTRY, 2018 (%) 50 FIGURE 16 EUROPE: AMNIOTIC MEMBRANE MARKET SHARE, BY REGION, 2018 (%) 56 FIGURE 17 WESTERN EUROPE: AMNIOTIC MEMBRANE MARKET SHARE, BY COUNTRY, 2018 (%) 58 FIGURE 18 ASIA-PACIFIC: AMNIOTIC MEMBRANE MARKET SHARE, BY COUNTRY, 2018 (%) 67 FIGURE 19 MIDDLE EAST & AFRICA: AMNIOTIC MEMBRANE MARKET SHARE, BY REGION, 2018 (%) 75 FIGURE 20 GLOBAL AMNIOTIC MEMBRANE MARKET SHARE ANALYSIS 2018 (%) 79

Applied Biologics (US), Alliqua BioMedical, Inc. (US), Integra LifeSciences (US), Skye Biologics Inc. (California), MiMedx (US), Amniox Medical, Inc. (Florida), Katena Products, Inc. (US), Human Regenerative Technologies, LLC (US), Amnio Technology, LLC (US), and Osiris Therapeutics, Inc. (US).