Table of Contents Executive Summary 1 Industry Overview of Orexin Receptor Type 2 1.1 Definition of Orexin Receptor Type 2 1.2 Orexin Receptor Type 2 Segment by Type 1.2.1 Global Orexin Receptor Type 2 Production Growth Rate Comparison by Types (2014-2025) 1.2.2 HTL-6641 1.2.3 MK-8133 1.2.4 Lemborexant 1.2.5 OPN-021 1.2.6 YNT-185 1.2.7 Others 1.3 Orexin Receptor Type 2 Segment by Applications 1.3.1 Global Orexin Receptor Type 2 Consumption Comparison by Applications (2014-2025) 1.3.2 Insomnia 1.3.3 Narcolepsy 1.3.4 Sleep Disorders 1.3.5 Major Depressive Disorder 1.4 Global Orexin Receptor Type 2 Overall Market 1.4.1 Global Orexin Receptor Type 2 Revenue (2014-2025) 1.4.2 Global Orexin Receptor Type 2 Production (2014-2025) 1.4.3 North America Orexin Receptor Type 2 Status and Prospect (2014-2025) 1.4.4 Europe Orexin Receptor Type 2 Status and Prospect (2014-2025) 1.4.5 China Orexin Receptor Type 2 Status and Prospect (2014-2025) 1.4.6 Japan Orexin Receptor Type 2 Status and Prospect (2014-2025) 1.4.7 Southeast Asia Orexin Receptor Type 2 Status and Prospect (2014-2025) 1.4.8 India Orexin Receptor Type 2 Status and Prospect (2014-2025) 2 Manufacturing Cost Structure Analysis 2.1 Raw Material and Suppliers 2.2 Manufacturing Cost Structure Analysis of Orexin Receptor Type 2 2.3 Manufacturing Process Analysis of Orexin Receptor Type 2 2.4 Industry Chain Structure of Orexin Receptor Type 2 3 Development and Manufacturing Plants Analysis of Orexin Receptor Type 2 3.1 Capacity and Commercial Production Date 3.2 Global Orexin Receptor Type 2 Manufacturing Plants Distribution 3.3 Major Manufacturers Technology Source and Market Position of Orexin Receptor Type 2 3.4 Recent Development and Expansion Plans 4 Key Figures of Major Manufacturers 4.1 Orexin Receptor Type 2 Production and Capacity Analysis 4.2 Orexin Receptor Type 2 Revenue Analysis 4.3 Orexin Receptor Type 2 Price Analysis 4.4 Market Concentration Degree 5 Orexin Receptor Type 2 Regional Market Analysis 5.1 Orexin Receptor Type 2 Production by Regions 5.1.1 Global Orexin Receptor Type 2 Production by Regions 5.1.2 Global Orexin Receptor Type 2 Revenue by Regions 5.2 Orexin Receptor Type 2 Consumption by Regions 5.3 North America Orexin Receptor Type 2 Market Analysis 5.3.1 North America Orexin Receptor Type 2 Production 5.3.2 North America Orexin Receptor Type 2 Revenue 5.3.3 Key Manufacturers in North America 5.3.4 North America Orexin Receptor Type 2 Import and Export 5.4 Europe Orexin Receptor Type 2 Market Analysis 5.4.1 Europe Orexin Receptor Type 2 Production 5.4.2 Europe Orexin Receptor Type 2 Revenue 5.4.3 Key Manufacturers in Europe 5.4.4 Europe Orexin Receptor Type 2 Import and Export 5.5 China Orexin Receptor Type 2 Market Analysis 5.5.1 China Orexin Receptor Type 2 Production 5.5.2 China Orexin Receptor Type 2 Revenue 5.5.3 Key Manufacturers in China 5.5.4 China Orexin Receptor Type 2 Import and Export 5.6 Japan Orexin Receptor Type 2 Market Analysis 5.6.1 Japan Orexin Receptor Type 2 Production 5.6.2 Japan Orexin Receptor Type 2 Revenue 5.6.3 Key Manufacturers in Japan 5.6.4 Japan Orexin Receptor Type 2 Import and Export 5.7 Southeast Asia Orexin Receptor Type 2 Market Analysis 5.7.1 Southeast Asia Orexin Receptor Type 2 Production 5.7.2 Southeast Asia Orexin Receptor Type 2 Revenue 5.7.3 Key Manufacturers in Southeast Asia 5.7.4 Southeast Asia Orexin Receptor Type 2 Import and Export 5.8 India Orexin Receptor Type 2 Market Analysis 5.8.1 India Orexin Receptor Type 2 Production 5.8.2 India Orexin Receptor Type 2 Revenue 5.8.3 Key Manufacturers in India 5.8.4 India Orexin Receptor Type 2 Import and Export 6 Orexin Receptor Type 2 Segment Market Analysis (by Type) 6.1 Global Orexin Receptor Type 2 Production by Type 6.2 Global Orexin Receptor Type 2 Revenue by Type 6.3 Orexin Receptor Type 2 Price by Type 7 Orexin Receptor Type 2 Segment Market Analysis (by Application) 7.1 Global Orexin Receptor Type 2 Consumption by Application 7.2 Global Orexin Receptor Type 2 Consumption Market Share by Application (2014-2019) 8 Orexin Receptor Type 2 Major Manufacturers Analysis 8.1 Actelion Pharmaceuticals Ltd 8.1.1 Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Production Sites and Area Served 8.1.2 Actelion Pharmaceuticals Ltd Product Introduction, Application and Specification 8.1.3 Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.1.4 Main Business and Markets Served 8.2 Eisai Co Ltd 8.2.1 Eisai Co Ltd Orexin Receptor Type 2 Production Sites and Area Served 8.2.2 Eisai Co Ltd Product Introduction, Application and Specification 8.2.3 Eisai Co Ltd Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.2.4 Main Business and Markets Served 8.3 Evotec AG 8.3.1 Evotec AG Orexin Receptor Type 2 Production Sites and Area Served 8.3.2 Evotec AG Product Introduction, Application and Specification 8.3.3 Evotec AG Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.3.4 Main Business and Markets Served 8.4 Heptares Therapeutics Ltd 8.4.1 Heptares Therapeutics Ltd Orexin Receptor Type 2 Production Sites and Area Served 8.4.2 Heptares Therapeutics Ltd Product Introduction, Application and Specification 8.4.3 Heptares Therapeutics Ltd Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.4.4 Main Business and Markets Served 8.5 Idorsia Ltd 8.5.1 Idorsia Ltd Orexin Receptor Type 2 Production Sites and Area Served 8.5.2 Idorsia Ltd Product Introduction, Application and Specification 8.5.3 Idorsia Ltd Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.5.4 Main Business and Markets Served 8.6 Johnson & Johnson 8.6.1 Johnson & Johnson Orexin Receptor Type 2 Production Sites and Area Served 8.6.2 Johnson & Johnson Product Introduction, Application and Specification 8.6.3 Johnson & Johnson Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.6.4 Main Business and Markets Served 8.7 Merck & Co Inc 8.7.1 Merck & Co Inc Orexin Receptor Type 2 Production Sites and Area Served 8.7.2 Merck & Co Inc Product Introduction, Application and Specification 8.7.3 Merck & Co Inc Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.7.4 Main Business and Markets Served 8.8 OptiNose US Inc 8.8.1 OptiNose US Inc Orexin Receptor Type 2 Production Sites and Area Served 8.8.2 OptiNose US Inc Product Introduction, Application and Specification 8.8.3 OptiNose US Inc Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.8.4 Main Business and Markets Served 8.9 Yangtze River Pharmaceutical Group 8.9.1 Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Production Sites and Area Served 8.9.2 Yangtze River Pharmaceutical Group Product Introduction, Application and Specification 8.9.3 Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.9.4 Main Business and Markets Served 9 Development Trend of Analysis of Orexin Receptor Type 2 Market 9.1 Global Orexin Receptor Type 2 Market Trend Analysis 9.1.1 Global Orexin Receptor Type 2 Market Size (Volume and Value) Forecast 2019-2025 9.2 Orexin Receptor Type 2 Regional Market Trend 9.2.1 North America Orexin Receptor Type 2 Forecast 2019-2025 9.2.2 Europe Orexin Receptor Type 2 Forecast 2019-2025 9.2.3 China Orexin Receptor Type 2 Forecast 2019-2025 9.2.4 Japan Orexin Receptor Type 2 Forecast 2019-2025 9.2.5 Southeast Asia Orexin Receptor Type 2 Forecast 2019-2025 9.2.6 India Orexin Receptor Type 2 Forecast 2019-2025 9.3 Orexin Receptor Type 2 Market Trend (Product Type) 9.4 Orexin Receptor Type 2 Market Trend (Application) 10.1 Marketing Channel 10.1.1 Direct Marketing 10.1.2 Indirect Marketing 10.3 Orexin Receptor Type 2 Customers 11 Market Dynamics 11.1 Market Trends 11.2 Opportunities 11.3 Market Drivers 11.4 Challenges 11.5 Influence Factors 12 Conclusion 13 Appendix 13.1 Methodology/Research Approach 13.1.1 Research Programs/Design 13.1.2 Market Size Estimation 13.1.3 Market Breakdown and Data Triangulation 13.2 Data Source 13.2.1 Secondary Sources 13.2.2 Primary Sources 13.3 Author List 13.4 Disclaimer

List of Tables and Figures Figure Picture of Orexin Receptor Type 2 Table Global Orexin Receptor Type 2 Production (K Pcs) Growth Rate Comparison by Types (2014-2025) Figure Global Orexin Receptor Type 2 Production Market Share by Types in 2018 Figure HTL-6641 Product Picture Figure MK-8133 Product Picture Figure Lemborexant Product Picture Figure OPN-021 Product Picture Figure YNT-185 Product Picture Figure Others Product Picture Table Global Orexin Receptor Type 2 Consumption (K Pcs) Comparison by Applications (2014-2025) Figure Global Orexin Receptor Type 2 Consumption Market Share by Applications in 2018 Figure Insomnia Figure Narcolepsy Figure Sleep Disorders Figure Major Depressive Disorder Figure Global Orexin Receptor Type 2 Revenue (Million USD) (2014-2025) Figure Global Orexin Receptor Type 2 Production (K Pcs) (2014-2025) Figure North America Orexin Receptor Type 2 Market Size (Million USD) (2014-2025) Figure Europe Orexin Receptor Type 2 Market Size (Million USD) (2014-2025) Figure China Orexin Receptor Type 2 Market Size (Million USD) (2014-2025) Figure Japan Orexin Receptor Type 2 Market Size (Million USD) (2014-2025) Figure Southeast Asia Orexin Receptor Type 2 Market Size (Million USD) (2014-2025) Figure India Orexin Receptor Type 2 Market Size (Million USD) (2014-2025) Table Orexin Receptor Type 2 Raw Material and Suppliers Table Manufacturing Cost Structure Analysis of Orexin Receptor Type 2 in 2018 Figure Manufacturing Process Analysis of Orexin Receptor Type 2 Figure Industry Chain Structure of Orexin Receptor Type 2 Table Capacity and Commercial Production Date of Key Manufacturers Table Global Orexin Receptor Type 2 Manufacturing Plants Distribution Table Orexin Receptor Type 2 Major Manufacturers Technology Source and Market Position Table Recent Development and Expansion Plans in Future Table Orexin Receptor Type 2 Capacity (K Pcs) of Major Manufacturers (2014-2019) Table Orexin Receptor Type 2 Production (K Pcs) of Major Manufacturers (2014-2019) Table Orexin Receptor Type 2 Production Market Share of Major Manufacturers (2014-2019) Figure Orexin Receptor Type 2 Production Share by Manufacturers in 2018 Table Orexin Receptor Type 2 Revenue (Million US$) of Major Manufacturers (2014-2019) Table Orexin Receptor Type 2 Revenue Market Share of Major Manufacturers (2014-2019) Figure Orexin Receptor Type 2 Revenue Share by Manufacturers in 2018 Table Orexin Receptor Type 2 Average Price (USD/Pcs) of Major Manufacturers (2014-2019) Table Global Manufacturers Market Concentration Ratio (CR5 and HHI) Table Global Orexin Receptor Type 2 Production by Regions 2014-2019 (K Pcs) Table Global Orexin Receptor Type 2 Production Market Share by Regions 2014-2019 Figure Global Orexin Receptor Type 2 Production Market Share by Regions in 2018 Table Global Orexin Receptor Type 2 Revenue by Regions 2014-2019 (Million USD) Table Global Orexin Receptor Type 2 Revenue Market Share by Regions 2014-2019 Figure Global Orexin Receptor Type 2 Revenue Market Share by Regions in 2018 Table Global Orexin Receptor Type 2 Consumption by Regions 2014-2019 (K Pcs) Table Global Orexin Receptor Type 2 Consumption Market Share by Regions 2014-2019 Figure North America Orexin Receptor Type 2 Production Growth Rate 2014-2019 (K Pcs) Figure North America Orexin Receptor Type 2 Revenue Growth Rate 2014-2019 (Million USD) Table North America Orexin Receptor Type 2 Production, Consumption Import and Export (K Pcs) Figure Europe Orexin Receptor Type 2 Production Growth Rate 2014-2019 (K Pcs) Figure Europe Orexin Receptor Type 2 Revenue Growth Rate 2014-2019 (Million USD) Table Europe Orexin Receptor Type 2 Production, Consumption Import and Export (K Pcs) Figure China Orexin Receptor Type 2 Production Growth Rate 2014-2019 (K Pcs) Figure China Orexin Receptor Type 2 Revenue Growth Rate 2014-2019 (Million USD) Table China Orexin Receptor Type 2 Production, Consumption Import and Export (K Pcs) Figure Japan Orexin Receptor Type 2 Production Growth Rate 2014-2019 (K Pcs) Figure Japan Orexin Receptor Type 2 Revenue Growth Rate 2014-2019 (Million USD) Table Japan Orexin Receptor Type 2 Production, Consumption Import and Export (K Pcs) Figure Southeast Asia Orexin Receptor Type 2 Production Growth Rate 2014-2019 (K Pcs) Figure Southeast Asia Orexin Receptor Type 2 Revenue Growth Rate 2014-2019 (Million USD) Table Southeast Asia Orexin Receptor Type 2 Production, Consumption Import and Export (K Pcs) Figure India Orexin Receptor Type 2 Production Growth Rate 2014-2019 (K Pcs) Figure India Orexin Receptor Type 2 Revenue Growth Rate 2014-2019 (Million USD) Table India Orexin Receptor Type 2 Production, Consumption Import and Export (K Pcs) Figure Global Consumption Orexin Receptor Type 2 Market Share by Application (2014-2019) Figure Global Value (Consumption) Orexin Receptor Type 2 Market Share by Application (2014-2019) Table Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Production Sites and Area Served Table Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Product Introduction, Application and Specification Table Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Actelion Pharmaceuticals Ltd Orexin Receptor Type 2 Main Business and Markets Served Table Eisai Co Ltd Orexin Receptor Type 2 Production Sites and Area Served Table Eisai Co Ltd Orexin Receptor Type 2 Product Introduction, Application and Specification Table Eisai Co Ltd Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Eisai Co Ltd Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Eisai Co Ltd Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Eisai Co Ltd Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Eisai Co Ltd Orexin Receptor Type 2 Main Business and Markets Served Table Evotec AG Orexin Receptor Type 2 Production Sites and Area Served Table Evotec AG Orexin Receptor Type 2 Product Introduction, Application and Specification Table Evotec AG Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Evotec AG Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Evotec AG Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Evotec AG Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Evotec AG Orexin Receptor Type 2 Main Business and Markets Served Table Heptares Therapeutics Ltd Orexin Receptor Type 2 Production Sites and Area Served Table Heptares Therapeutics Ltd Orexin Receptor Type 2 Product Introduction, Application and Specification Table Heptares Therapeutics Ltd Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Heptares Therapeutics Ltd Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Heptares Therapeutics Ltd Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Heptares Therapeutics Ltd Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Heptares Therapeutics Ltd Orexin Receptor Type 2 Main Business and Markets Served Table Idorsia Ltd Orexin Receptor Type 2 Production Sites and Area Served Table Idorsia Ltd Orexin Receptor Type 2 Product Introduction, Application and Specification Table Idorsia Ltd Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Idorsia Ltd Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Idorsia Ltd Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Idorsia Ltd Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Idorsia Ltd Orexin Receptor Type 2 Main Business and Markets Served Table Johnson & Johnson Orexin Receptor Type 2 Production Sites and Area Served Table Johnson & Johnson Orexin Receptor Type 2 Product Introduction, Application and Specification Table Johnson & Johnson Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Johnson & Johnson Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Johnson & Johnson Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Johnson & Johnson Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Johnson & Johnson Orexin Receptor Type 2 Main Business and Markets Served Table Merck & Co Inc Orexin Receptor Type 2 Production Sites and Area Served Table Merck & Co Inc Orexin Receptor Type 2 Product Introduction, Application and Specification Table Merck & Co Inc Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Merck & Co Inc Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Merck & Co Inc Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Merck & Co Inc Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Merck & Co Inc Orexin Receptor Type 2 Main Business and Markets Served Table OptiNose US Inc Orexin Receptor Type 2 Production Sites and Area Served Table OptiNose US Inc Orexin Receptor Type 2 Product Introduction, Application and Specification Table OptiNose US Inc Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table OptiNose US Inc Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table OptiNose US Inc Orexin Receptor Type 2 Production Market Share (2014-2019) Figure OptiNose US Inc Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table OptiNose US Inc Orexin Receptor Type 2 Main Business and Markets Served Table Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Production Sites and Area Served Table Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Product Introduction, Application and Specification Table Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Production (K Pcs), Revenue (Million USD), Ex-factory Price (USD/Pcs) and Gross Margin (2014-2019) Table Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Production Growth Rate (2014-2019) Table Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Production Market Share (2014-2019) Figure Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Revenue Market Share (2014-2019) Table Yangtze River Pharmaceutical Group Orexin Receptor Type 2 Main Business and Markets Served Figure Global Orexin Receptor Type 2 Production (K Pcs) Growth Rate Forecast 2019-2025 Figure Global Orexin Receptor Type 2 Revenue (Million USD) Growth Rate Forecast 2019-2025 Figure Global Orexin Receptor Type 2 Sales Price (USD/Pcs) Forecast 2019-2025 Figure North America Orexin Receptor Type 2 Production Growth Rate Forecast 2019-2025 (K Pcs) Figure North America Orexin Receptor Type 2 Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure Europe Orexin Receptor Type 2 Production Growth Rate Forecast 2019-2025 (K Pcs) Figure Europe Orexin Receptor Type 2 Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure China Orexin Receptor Type 2 Production Growth Rate Forecast 2019-2025 (K Pcs) Figure China Orexin Receptor Type 2 Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure Japan Orexin Receptor Type 2 Production Growth Rate Forecast 2019-2025 (K Pcs) Figure Japan Orexin Receptor Type 2 Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure Southeast Asia Orexin Receptor Type 2 Production Growth Rate Forecast 2019-2025 (K Pcs) Figure Southeast Asia Orexin Receptor Type 2 Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure India Orexin Receptor Type 2 Production Growth Rate Forecast 2019-2025 (K Pcs) Figure India Orexin Receptor Type 2 Revenue Growth Rate Forecast 2019-2025 (Million USD) Table Global Production (K Pcs) of Orexin Receptor Type 2 by Type (2019-2025) Table Global Consumption (K Pcs) of Orexin Receptor Type 2 by Application (2019-2025) Table Orexin Receptor Type 2 Distributors List Table Orexin Receptor Type 2 Customers List Table Market Key Trends Table Key Opportunities Table Market Key Drivers Table Key Challenges Table Key Influence Factors Table Research Programs/Design for This Report Figure Bottom-up and Top-down Approaches for This Report Figure Data Triangulation Table Key Data Information from Secondary Sources Table Key Data Information from Primary Sources

Actelion Pharmaceuticals Ltd Eisai Co Ltd Evotec AG Heptares Therapeutics Ltd Idorsia Ltd Johnson & Johnson Merck & Co Inc OptiNose US Inc Yangtze River Pharmaceutical Group