Table of Contents Executive Summary 1 Industry Overview of Antisense and RNAi Therapeutics 1.1 Definition of Antisense and RNAi Therapeutics 1.2 Antisense and RNAi Therapeutics Segment by Type 1.2.1 Global Antisense and RNAi Therapeutics Production Growth Rate Comparison by Types (2014-2025) 1.2.2 RNA Interference 1.2.3 Antisense RNA 1.3 Antisense and RNAi Therapeutics Segment by Applications 1.3.1 Global Antisense and RNAi Therapeutics Consumption Comparison by Applications (2014-2025) 1.3.2 Hospital 1.3.3 Clinic 1.4 Global Antisense and RNAi Therapeutics Overall Market 1.4.1 Global Antisense and RNAi Therapeutics Revenue (2014-2025) 1.4.2 Global Antisense and RNAi Therapeutics Production (2014-2025) 1.4.3 North America Antisense and RNAi Therapeutics Status and Prospect (2014-2025) 1.4.4 Europe Antisense and RNAi Therapeutics Status and Prospect (2014-2025) 1.4.5 China Antisense and RNAi Therapeutics Status and Prospect (2014-2025) 1.4.6 Japan Antisense and RNAi Therapeutics Status and Prospect (2014-2025) 1.4.7 Southeast Asia Antisense and RNAi Therapeutics Status and Prospect (2014-2025) 1.4.8 India Antisense and RNAi Therapeutics Status and Prospect (2014-2025) 2 Manufacturing Cost Structure Analysis 2.1 Raw Material and Suppliers 2.2 Manufacturing Cost Structure Analysis of Antisense and RNAi Therapeutics 2.3 Manufacturing Process Analysis of Antisense and RNAi Therapeutics 2.4 Industry Chain Structure of Antisense and RNAi Therapeutics 3 Development and Manufacturing Plants Analysis of Antisense and RNAi Therapeutics 3.1 Capacity and Commercial Production Date 3.2 Global Antisense and RNAi Therapeutics Manufacturing Plants Distribution 3.3 Major Manufacturers Technology Source and Market Position of Antisense and RNAi Therapeutics 3.4 Recent Development and Expansion Plans 4 Key Figures of Major Manufacturers 4.1 Antisense and RNAi Therapeutics Production and Capacity Analysis 4.2 Antisense and RNAi Therapeutics Revenue Analysis 4.3 Antisense and RNAi Therapeutics Price Analysis 4.4 Market Concentration Degree 5 Antisense and RNAi Therapeutics Regional Market Analysis 5.1 Antisense and RNAi Therapeutics Production by Regions 5.1.1 Global Antisense and RNAi Therapeutics Production by Regions 5.1.2 Global Antisense and RNAi Therapeutics Revenue by Regions 5.2 Antisense and RNAi Therapeutics Consumption by Regions 5.3 North America Antisense and RNAi Therapeutics Market Analysis 5.3.1 North America Antisense and RNAi Therapeutics Production 5.3.2 North America Antisense and RNAi Therapeutics Revenue 5.3.3 Key Manufacturers in North America 5.3.4 North America Antisense and RNAi Therapeutics Import and Export 5.4 Europe Antisense and RNAi Therapeutics Market Analysis 5.4.1 Europe Antisense and RNAi Therapeutics Production 5.4.2 Europe Antisense and RNAi Therapeutics Revenue 5.4.3 Key Manufacturers in Europe 5.4.4 Europe Antisense and RNAi Therapeutics Import and Export 5.5 China Antisense and RNAi Therapeutics Market Analysis 5.5.1 China Antisense and RNAi Therapeutics Production 5.5.2 China Antisense and RNAi Therapeutics Revenue 5.5.3 Key Manufacturers in China 5.5.4 China Antisense and RNAi Therapeutics Import and Export 5.6 Japan Antisense and RNAi Therapeutics Market Analysis 5.6.1 Japan Antisense and RNAi Therapeutics Production 5.6.2 Japan Antisense and RNAi Therapeutics Revenue 5.6.3 Key Manufacturers in Japan 5.6.4 Japan Antisense and RNAi Therapeutics Import and Export 5.7 Southeast Asia Antisense and RNAi Therapeutics Market Analysis 5.7.1 Southeast Asia Antisense and RNAi Therapeutics Production 5.7.2 Southeast Asia Antisense and RNAi Therapeutics Revenue 5.7.3 Key Manufacturers in Southeast Asia 5.7.4 Southeast Asia Antisense and RNAi Therapeutics Import and Export 5.8 India Antisense and RNAi Therapeutics Market Analysis 5.8.1 India Antisense and RNAi Therapeutics Production 5.8.2 India Antisense and RNAi Therapeutics Revenue 5.8.3 Key Manufacturers in India 5.8.4 India Antisense and RNAi Therapeutics Import and Export 6 Antisense and RNAi Therapeutics Segment Market Analysis (by Type) 6.1 Global Antisense and RNAi Therapeutics Production by Type 6.2 Global Antisense and RNAi Therapeutics Revenue by Type 6.3 Antisense and RNAi Therapeutics Price by Type 7 Antisense and RNAi Therapeutics Segment Market Analysis (by Application) 7.1 Global Antisense and RNAi Therapeutics Consumption by Application 7.2 Global Antisense and RNAi Therapeutics Consumption Market Share by Application (2014-2019) 8 Antisense and RNAi Therapeutics Major Manufacturers Analysis 8.1 Tekmira Pharmaceuticals 8.1.1 Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Production Sites and Area Served 8.1.2 Tekmira Pharmaceuticals Product Introduction, Application and Specification 8.1.3 Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.1.4 Main Business and Markets Served 8.2 Arbutus Biopharma 8.2.1 Arbutus Biopharma Antisense and RNAi Therapeutics Production Sites and Area Served 8.2.2 Arbutus Biopharma Product Introduction, Application and Specification 8.2.3 Arbutus Biopharma Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.2.4 Main Business and Markets Served 8.3 Alnylam Pharmaceuticals 8.3.1 Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Production Sites and Area Served 8.3.2 Alnylam Pharmaceuticals Product Introduction, Application and Specification 8.3.3 Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.3.4 Main Business and Markets Served 8.4 Antisense Therapeutics 8.4.1 Antisense Therapeutics Antisense and RNAi Therapeutics Production Sites and Area Served 8.4.2 Antisense Therapeutics Product Introduction, Application and Specification 8.4.3 Antisense Therapeutics Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.4.4 Main Business and Markets Served 8.5 Silence Therapeutics 8.5.1 Silence Therapeutics Antisense and RNAi Therapeutics Production Sites and Area Served 8.5.2 Silence Therapeutics Product Introduction, Application and Specification 8.5.3 Silence Therapeutics Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.5.4 Main Business and Markets Served 8.6 Isis Pharmaceuticals 8.6.1 Isis Pharmaceuticals Antisense and RNAi Therapeutics Production Sites and Area Served 8.6.2 Isis Pharmaceuticals Product Introduction, Application and Specification 8.6.3 Isis Pharmaceuticals Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.6.4 Main Business and Markets Served 8.7 Sirnaomics 8.7.1 Sirnaomics Antisense and RNAi Therapeutics Production Sites and Area Served 8.7.2 Sirnaomics Product Introduction, Application and Specification 8.7.3 Sirnaomics Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.7.4 Main Business and Markets Served 8.8 Santaris 8.8.1 Santaris Antisense and RNAi Therapeutics Production Sites and Area Served 8.8.2 Santaris Product Introduction, Application and Specification 8.8.3 Santaris Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.8.4 Main Business and Markets Served 8.9 Roche 8.9.1 Roche Antisense and RNAi Therapeutics Production Sites and Area Served 8.9.2 Roche Product Introduction, Application and Specification 8.9.3 Roche Antisense and RNAi Therapeutics Production, Revenue, Ex-factory Price and Gross Margin (2014-2019) 8.9.4 Main Business and Markets Served 9 Development Trend of Analysis of Antisense and RNAi Therapeutics Market 9.1 Global Antisense and RNAi Therapeutics Market Trend Analysis 9.1.1 Global Antisense and RNAi Therapeutics Market Size (Volume and Value) Forecast 2019-2025 9.2 Antisense and RNAi Therapeutics Regional Market Trend 9.2.1 North America Antisense and RNAi Therapeutics Forecast 2019-2025 9.2.2 Europe Antisense and RNAi Therapeutics Forecast 2019-2025 9.2.3 China Antisense and RNAi Therapeutics Forecast 2019-2025 9.2.4 Japan Antisense and RNAi Therapeutics Forecast 2019-2025 9.2.5 Southeast Asia Antisense and RNAi Therapeutics Forecast 2019-2025 9.2.6 India Antisense and RNAi Therapeutics Forecast 2019-2025 9.3 Antisense and RNAi Therapeutics Market Trend (Product Type) 9.4 Antisense and RNAi Therapeutics Market Trend (Application) 10.1 Marketing Channel 10.1.1 Direct Marketing 10.1.2 Indirect Marketing 10.3 Antisense and RNAi Therapeutics Customers 11 Market Dynamics 11.1 Market Trends 11.2 Opportunities 11.3 Market Drivers 11.4 Challenges 11.5 Influence Factors 12 Conclusion 13 Appendix 13.1 Methodology/Research Approach 13.1.1 Research Programs/Design 13.1.2 Market Size Estimation 13.1.3 Market Breakdown and Data Triangulation 13.2 Data Source 13.2.1 Secondary Sources 13.2.2 Primary Sources 13.3 Author List 13.4 Disclaimer

List of Tables and Figures Figure Picture of Antisense and RNAi Therapeutics Table Global Antisense and RNAi Therapeutics Production (K Units) Growth Rate Comparison by Types (2014-2025) Figure Global Antisense and RNAi Therapeutics Production Market Share by Types in 2018 Figure RNA Interference Product Picture Figure Antisense RNA Product Picture Table Global Antisense and RNAi Therapeutics Consumption (K Units) Comparison by Applications (2014-2025) Figure Global Antisense and RNAi Therapeutics Consumption Market Share by Applications in 2018 Figure Hospital Figure Clinic Figure Global Antisense and RNAi Therapeutics Revenue (Million USD) (2014-2025) Figure Global Antisense and RNAi Therapeutics Production (K Units) (2014-2025) Figure North America Antisense and RNAi Therapeutics Market Size (Million USD) (2014-2025) Figure Europe Antisense and RNAi Therapeutics Market Size (Million USD) (2014-2025) Figure China Antisense and RNAi Therapeutics Market Size (Million USD) (2014-2025) Figure Japan Antisense and RNAi Therapeutics Market Size (Million USD) (2014-2025) Figure Southeast Asia Antisense and RNAi Therapeutics Market Size (Million USD) (2014-2025) Figure India Antisense and RNAi Therapeutics Market Size (Million USD) (2014-2025) Table Antisense and RNAi Therapeutics Raw Material and Suppliers Table Manufacturing Cost Structure Analysis of Antisense and RNAi Therapeutics in 2018 Figure Manufacturing Process Analysis of Antisense and RNAi Therapeutics Figure Industry Chain Structure of Antisense and RNAi Therapeutics Table Capacity and Commercial Production Date of Key Manufacturers Table Global Antisense and RNAi Therapeutics Manufacturing Plants Distribution Table Antisense and RNAi Therapeutics Major Manufacturers Technology Source and Market Position Table Recent Development and Expansion Plans in Future Table Antisense and RNAi Therapeutics Capacity (K Units) of Major Manufacturers (2014-2019) Table Antisense and RNAi Therapeutics Production (K Units) of Major Manufacturers (2014-2019) Table Antisense and RNAi Therapeutics Production Market Share of Major Manufacturers (2014-2019) Figure Antisense and RNAi Therapeutics Production Share by Manufacturers in 2018 Table Antisense and RNAi Therapeutics Revenue (Million US$) of Major Manufacturers (2014-2019) Table Antisense and RNAi Therapeutics Revenue Market Share of Major Manufacturers (2014-2019) Figure Antisense and RNAi Therapeutics Revenue Share by Manufacturers in 2018 Table Antisense and RNAi Therapeutics Average Price (USD/Unit) of Major Manufacturers (2014-2019) Table Global Manufacturers Market Concentration Ratio (CR5 and HHI) Table Global Antisense and RNAi Therapeutics Production by Regions 2014-2019 (K Units) Table Global Antisense and RNAi Therapeutics Production Market Share by Regions 2014-2019 Figure Global Antisense and RNAi Therapeutics Production Market Share by Regions in 2018 Table Global Antisense and RNAi Therapeutics Revenue by Regions 2014-2019 (Million USD) Table Global Antisense and RNAi Therapeutics Revenue Market Share by Regions 2014-2019 Figure Global Antisense and RNAi Therapeutics Revenue Market Share by Regions in 2018 Table Global Antisense and RNAi Therapeutics Consumption by Regions 2014-2019 (K Units) Table Global Antisense and RNAi Therapeutics Consumption Market Share by Regions 2014-2019 Figure North America Antisense and RNAi Therapeutics Production Growth Rate 2014-2019 (K Units) Figure North America Antisense and RNAi Therapeutics Revenue Growth Rate 2014-2019 (Million USD) Table North America Antisense and RNAi Therapeutics Production, Consumption Import and Export (K Units) Figure Europe Antisense and RNAi Therapeutics Production Growth Rate 2014-2019 (K Units) Figure Europe Antisense and RNAi Therapeutics Revenue Growth Rate 2014-2019 (Million USD) Table Europe Antisense and RNAi Therapeutics Production, Consumption Import and Export (K Units) Figure China Antisense and RNAi Therapeutics Production Growth Rate 2014-2019 (K Units) Figure China Antisense and RNAi Therapeutics Revenue Growth Rate 2014-2019 (Million USD) Table China Antisense and RNAi Therapeutics Production, Consumption Import and Export (K Units) Figure Japan Antisense and RNAi Therapeutics Production Growth Rate 2014-2019 (K Units) Figure Japan Antisense and RNAi Therapeutics Revenue Growth Rate 2014-2019 (Million USD) Table Japan Antisense and RNAi Therapeutics Production, Consumption Import and Export (K Units) Figure Southeast Asia Antisense and RNAi Therapeutics Production Growth Rate 2014-2019 (K Units) Figure Southeast Asia Antisense and RNAi Therapeutics Revenue Growth Rate 2014-2019 (Million USD) Table Southeast Asia Antisense and RNAi Therapeutics Production, Consumption Import and Export (K Units) Figure India Antisense and RNAi Therapeutics Production Growth Rate 2014-2019 (K Units) Figure India Antisense and RNAi Therapeutics Revenue Growth Rate 2014-2019 (Million USD) Table India Antisense and RNAi Therapeutics Production, Consumption Import and Export (K Units) Figure Global Consumption Antisense and RNAi Therapeutics Market Share by Application (2014-2019) Figure Global Value (Consumption) Antisense and RNAi Therapeutics Market Share by Application (2014-2019) Table Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Production Sites and Area Served Table Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Tekmira Pharmaceuticals Antisense and RNAi Therapeutics Main Business and Markets Served Table Arbutus Biopharma Antisense and RNAi Therapeutics Production Sites and Area Served Table Arbutus Biopharma Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Arbutus Biopharma Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Arbutus Biopharma Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Arbutus Biopharma Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Arbutus Biopharma Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Arbutus Biopharma Antisense and RNAi Therapeutics Main Business and Markets Served Table Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Production Sites and Area Served Table Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Alnylam Pharmaceuticals Antisense and RNAi Therapeutics Main Business and Markets Served Table Antisense Therapeutics Antisense and RNAi Therapeutics Production Sites and Area Served Table Antisense Therapeutics Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Antisense Therapeutics Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Antisense Therapeutics Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Antisense Therapeutics Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Antisense Therapeutics Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Antisense Therapeutics Antisense and RNAi Therapeutics Main Business and Markets Served Table Silence Therapeutics Antisense and RNAi Therapeutics Production Sites and Area Served Table Silence Therapeutics Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Silence Therapeutics Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Silence Therapeutics Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Silence Therapeutics Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Silence Therapeutics Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Silence Therapeutics Antisense and RNAi Therapeutics Main Business and Markets Served Table Isis Pharmaceuticals Antisense and RNAi Therapeutics Production Sites and Area Served Table Isis Pharmaceuticals Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Isis Pharmaceuticals Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Isis Pharmaceuticals Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Isis Pharmaceuticals Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Isis Pharmaceuticals Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Isis Pharmaceuticals Antisense and RNAi Therapeutics Main Business and Markets Served Table Sirnaomics Antisense and RNAi Therapeutics Production Sites and Area Served Table Sirnaomics Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Sirnaomics Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Sirnaomics Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Sirnaomics Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Sirnaomics Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Sirnaomics Antisense and RNAi Therapeutics Main Business and Markets Served Table Santaris Antisense and RNAi Therapeutics Production Sites and Area Served Table Santaris Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Santaris Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Santaris Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Santaris Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Santaris Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Santaris Antisense and RNAi Therapeutics Main Business and Markets Served Table Roche Antisense and RNAi Therapeutics Production Sites and Area Served Table Roche Antisense and RNAi Therapeutics Product Introduction, Application and Specification Table Roche Antisense and RNAi Therapeutics Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019) Table Roche Antisense and RNAi Therapeutics Production Growth Rate (2014-2019) Table Roche Antisense and RNAi Therapeutics Production Market Share (2014-2019) Figure Roche Antisense and RNAi Therapeutics Revenue Market Share (2014-2019) Table Roche Antisense and RNAi Therapeutics Main Business and Markets Served Figure Global Antisense and RNAi Therapeutics Production (K Units) Growth Rate Forecast 2019-2025 Figure Global Antisense and RNAi Therapeutics Revenue (Million USD) Growth Rate Forecast 2019-2025 Figure Global Antisense and RNAi Therapeutics Sales Price (USD/Unit) Forecast 2019-2025 Figure North America Antisense and RNAi Therapeutics Production Growth Rate Forecast 2019-2025 (K Units) Figure North America Antisense and RNAi Therapeutics Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure Europe Antisense and RNAi Therapeutics Production Growth Rate Forecast 2019-2025 (K Units) Figure Europe Antisense and RNAi Therapeutics Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure China Antisense and RNAi Therapeutics Production Growth Rate Forecast 2019-2025 (K Units) Figure China Antisense and RNAi Therapeutics Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure Japan Antisense and RNAi Therapeutics Production Growth Rate Forecast 2019-2025 (K Units) Figure Japan Antisense and RNAi Therapeutics Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure Southeast Asia Antisense and RNAi Therapeutics Production Growth Rate Forecast 2019-2025 (K Units) Figure Southeast Asia Antisense and RNAi Therapeutics Revenue Growth Rate Forecast 2019-2025 (Million USD) Figure India Antisense and RNAi Therapeutics Production Growth Rate Forecast 2019-2025 (K Units) Figure India Antisense and RNAi Therapeutics Revenue Growth Rate Forecast 2019-2025 (Million USD) Table Global Production (K Units) of Antisense and RNAi Therapeutics by Type (2019-2025) Table Global Consumption (K Units) of Antisense and RNAi Therapeutics by Application (2019-2025) Table Antisense and RNAi Therapeutics Distributors List Table Antisense and RNAi Therapeutics Customers List Table Market Key Trends Table Key Opportunities Table Market Key Drivers Table Key Challenges Table Key Influence Factors Table Research Programs/Design for This Report Figure Bottom-up and Top-down Approaches for This Report Figure Data Triangulation Table Key Data Information from Secondary Sources Table Key Data Information from Primary Sources

Tekmira Pharmaceuticals Arbutus Biopharma Alnylam Pharmaceuticals Antisense Therapeutics Silence Therapeutics Isis Pharmaceuticals Sirnaomics Santaris Roche