PART 01: EXECUTIVE SUMMARY PART 02: SCOPE OF THE REPORT PART 03: RESEARCH METHODOLOGY PART 04: MARKET LANDSCAPE • Market ecosystem • Market characteristics • Market segmentation analysis PART 05: MARKET SIZING • Market definition • Market size and forecast 2017-2022 PART 06: FIVE FORCES ANALYSIS • Bargaining power of buyers • Bargaining power of suppliers • Threat of new entrants • Threat of substitutes • Threat of rivalry • Market condition PART 07: MARKET SEGMENTATION BY PRODUCT • Segmentation by product • Comparison by product • Implants and instrumentation – Market size and forecast 2017-2022 • Spine biologics – Market size and forecast 2017-2022 • Market opportunity by product PART 08: MARKET SEGMENTATION BY METHOD • Segmentation by method • Spinal fusion devices – Market size and forecast 2017-2022 • Spinal non-fusion devices – Market size and forecast 2017-2022 • Market opportunity by method PART 09: MARKET SEGMENTATION BY PROCEDURE • Segmentation by procedure • Open surgery • MIS PART 10: CUSTOMER LANDSCAPE PART 11: MARKET SEGMENTATION BY END-USER • Segmentation by end-user • Hospitals • ASCs • Specialty orthopedic centers PART 12: REGIONAL LANDSCAPE • Geographical segmentation • Regional comparison • Americas – Market size and forecast 2017-2022 • EMEA – Market size and forecast 2017-2022 • APAC – Market size and forecast 2017-2022 • Market opportunity PART 13: DECISION FRAMEWORK PART 14: DRIVERS AND CHALLENGES • Market drivers • Market challenges PART 15: MARKET TRENDS • Increase in demand for spine biologics • Growing focus on developing custom implants • Emergence of robotic image guidance techniques and platforms • New product launches PART 16: VENDOR LANDSCAPE • Overview • Landscape disruption PART 17: VENDOR ANALYSIS • Vendors covered • Vendor classification • Market positioning of vendors • DePuy Synthes • Globus Medical • Medtronic • NuVasive • Stryker • Zimmer Biomet PART 18: APPENDIX • List of abbreviations Exhibit 01: Parent market Exhibit 02: Global orthopedic devices market Exhibit 03: Market characteristics Exhibit 04: Market segments Exhibit 05: Market definition - Inclusions and exclusions checklist Exhibit 06: Market size 2017 Exhibit 07: Validation techniques employed for market sizing 2017 Exhibit 08: Global spinal surgery devices – Market size and forecast 2017-2022 ($ bn) Exhibit 09: Global spinal surgery devices market – Year-over-year growth 2018-2022 (%) Exhibit 10: Five forces analysis 2017 Exhibit 11: Five forces analysis 2022 Exhibit 12: Bargaining power of buyers Exhibit 13: Bargaining power of suppliers Exhibit 14: Threat of new entrants Exhibit 15: Threat of substitutes Exhibit 16: Threat of rivalry Exhibit 17: Market condition - Five forces 2017 Exhibit 18: Product – Market share 2017-2022 (%) Exhibit 19: Comparison by product Exhibit 20: Implants and instrumentation – Market size and forecast 2017-2022 ($ bn) Exhibit 21: Implants and instrumentation – Year-over-year growth 2018-2022 (%) Exhibit 22: Spine biologics – Market size and forecast 2017-2022 ($ bn) Exhibit 23: Spine biologics – Year-over-year growth 2018-2022 (%) Exhibit 24: Market opportunity by product Exhibit 25: Method – Market share 2017-2022 (%) Exhibit 26: Comparison by method Exhibit 27: Spinal fusion devices – Market size and forecast 2017-2022 ($ bn) Exhibit 28: Spinal fusion devices – Year-over-year growth 2018-2022 (%) Exhibit 29: Spinal non-fusion devices – Market size and forecast 2017-2022 ($ bn) Exhibit 30: Spinal non-fusion devices – Year-over-year growth 2018-2022 (%) Exhibit 31: Market opportunity by method Exhibit 32: Segmentation of global spinal surgery devices market by procedure 2017 (%) Exhibit 33: Customer landscape Exhibit 34: Segmentation by end-user 2017 (%) Exhibit 35: Spinal surgery devices – Market share by geography 2017-2022 (%) Exhibit 36: Regional comparison Exhibit 37: Americas – Market size and forecast 2017-2022 ($ bn) Exhibit 38: Americas – Year-over-year growth 2018-2022 (%) Exhibit 39: Top three countries in Americas Exhibit 40: EMEA – Market size and forecast 2017-2022 ($ bn) Exhibit 41: EMEA – Year-over-year growth 2018-2022 (%) Exhibit 42: Top three countries in EMEA Exhibit 43: APAC – Market size and forecast 2017-2022 ($ bn) Exhibit 44: APAC – Year-over-year growth 2018-2022 (%) Exhibit 45: Top three countries in APAC Exhibit 46: Market opportunity Exhibit 47: New product launches Exhibit 48: Vendor landscape Exhibit 49: Landscape disruption Exhibit 50: Vendors covered Exhibit 51: Vendor classification Exhibit 52: Market positioning of vendors Exhibit 53: DePuy Synthes – Overview Exhibit 54: DePuy Synthes – Business segments Exhibit 55: DePuy Synthes – Organizational developments Exhibit 56: DePuy Synthes – Geographic focus Exhibit 57: DePuy Synthes – Segment focus Exhibit 58: DePuy Synthes – Key offerings Exhibit 59: DePuy Synthes – Key customers Exhibit 60: Globus Medical – Overview Exhibit 61: Globus Medical – Product categories Exhibit 62: Globus Medical – Organizational developments Exhibit 63: Globus Medical – Geographic focus Exhibit 64: Globus Medical – Segment focus Exhibit 65: Globus Medical – Key offerings Exhibit 66: Globus Medical – Key customers Exhibit 67: Medtronic – Overview Exhibit 68: Medtronic – Business segments Exhibit 69: Medtronic – Organizational developments Exhibit 70: Medtronic – Geographic focus Exhibit 71: Medtronic – Segment focus Exhibit 72: Medtronic – Key offerings Exhibit 73: Medtronic – Key customers Exhibit 74: NuVasive – Overview Exhibit 75: NuVasive – Product lines Exhibit 76: NuVasive – Organizational developments Exhibit 77: NuVasive – Geographic focus Exhibit 78: NuVasive – Segment focus Exhibit 79: NuVasive – Key offerings Exhibit 80: NuVasive – Key customers Exhibit 81: Stryker – Overview Exhibit 82: Stryker – Business segments Exhibit 83: Stryker – Organizational developments Exhibit 84: Stryker – Geographic focus Exhibit 85: Stryker – Segment focus Exhibit 86: Stryker – Key offerings Exhibit 87: Stryker – Key customers Exhibit 88: Zimmer Biomet – Overview Exhibit 89: Zimmer Biomet – Business segments Exhibit 90: Zimmer Biomet – Organizational developments Exhibit 91: Zimmer Biomet – Geographic focus Exhibit 92: Zimmer Biomet – Segment focus Exhibit 93: Zimmer Biomet – Key offerings Exhibit 94: Zimmer Biomet – Key customers

DePuy Synthes, Globus Medical, Medtronic, NuVasive, Stryker, and Zimmer Biomet.