Overview Age-Related Macular Degeneration Risk factors for AMD Wet AMD - Pathogenesis Wet AMD – Clinical Features & Diagnosis Wet AMD – Treatment Options Pipeline Therapeutics (Active Products) Comparative Analysis Late Stage Products (Phase III) Comparative Analysis Abicipar: Allergan Product Description Research and Development Product Development Activities (The list continues) Mid Stage Products (Phase II) Comparative Analysis Early Stage Products (Phase I) Comparative Analysis Pre-clinical & Discovery Stage Products Therapeutic Assessment: Active Products Assessment by Monotherapy Products Assessment by Combination Products Assessment by Route of Administration Assessment by Stage and Route of Administration Assessment by Molecule Type Assessment by Stage and Molecule Type Inactive Products Appendix

Table 1: Total Products for Wet Age-related Macular Degeneration Table 2: Late Stage Products (Phase III) Table 3: Mid Stage Products (Phase II) Table 4: Early Stage Products (Phase I) Table 5: List of Pre-clinical & Discovery Products Table 6: Assessment by Monotherapy Products Table 7: Assessment by Combination Products Table 8: Assessment by Route of Administration Table 9: Assessment by Stage and Route of Administration Table 10: Assessment by Molecule Type Table 11: Assessment by Stage and Molecule Type Table 12: List of Inactive Products Figure 1: Fundus photographs of healthy and AMD affected eyes Figure 2: Progression of AMD Figure 3: Mechanism of Neovascularisation Figure 4: Total Products for Wet Age-related Macular Degeneration Figure 5: Late Stage Products (Phase III) Figure 6: Mid Stage Products (Phase II) Figure 7: Early Stage Products (Phase I and IND) Figure 8: Pre-clinical & Discovery Stage Products Figure 9: Assessment by Monotherapy Products Figure 10: Assessment by Combination Products Figure 11: Assessment by Route of Administration Figure 12: Assessment by Stage and Route of Administration

Aciont Acucela Adalta Adverum Biotechnologies Aerie Pharmaceuticals Alimera sciences Allegro Opthalmics Allergan Allergan Altacor Apexigen Ascendis Pharma Bayer Benitech Biopharma Biolight life sciences BioMAS Boehringer Ingelheim Charlesson Clanotech Coherus Biosciences CoMentis Daiichi Sankyo Exonate Genera Corporation GenVec GlaxoSmithKline GreyBug Vision Healios Hemera Biosciences Iconic Therapeutics Janssen Jerini Opthalmic Kalos therapeutics Kodiac Sciences Light Sciences Lpath MeiraGTx Neurotech Novartis Occurx Ocugen Ocular Therapeutix OHR Pharmaceutical OliX Pharmaceuticals Omeros OPKO Health Opthea Opthotech Corporation Oxford Biomedica Paloma Pharmaceuticals PanOptica Pfizer pSivida Quark Regeneron REGENXBIO Roche RXI Pharmaceuticals S & I Ophthalmic Sanofi Santen Santen Pharmaceutical SciFluor Life Sciences ThromboGenics Tyrogenex