1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 4 1.2 List of Figures 5 2 Introduction 6 2.1 Respiratory Assist Devices Overview 6 3 Products under Development 7 3.1 Respiratory Assist Devices - Pipeline Products by Stage of Development 7 3.2 Respiratory Assist Devices - Pipeline Products by Segment 8 3.3 Respiratory Assist Devices - Pipeline Products by Territory 9 3.4 Respiratory Assist Devices - Pipeline Products by Regulatory Path 10 3.5 Respiratory Assist Devices - Pipeline Products by Estimated Approval Date 11 3.6 Respiratory Assist Devices - Ongoing Clinical Trials 12 4 Respiratory Assist Devices - Pipeline Products under Development by Companies 13 4.1 Respiratory Assist Devices Companies - Pipeline Products by Stage of Development 13 4.2 Respiratory Assist Devices - Pipeline Products by Stage of Development 14 5 Respiratory Assist Devices Companies and Product Overview 15 5.1 Advanced Respiratory Technologies LLC Company Overview 15 5.1.1 Advanced Respiratory Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview 15 5.2 ALung Technologies Inc Company Overview 16 5.2.1 ALung Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 16 5.3 Breethe, Inc. Company Overview 21 5.3.1 Breethe, Inc. Pipeline Products & Ongoing Clinical Trials Overview 21 5.4 Case Western Reserve University Company Overview 22 5.4.1 Case Western Reserve University Pipeline Products & Ongoing Clinical Trials Overview 22 5.5 enmodes GmbH Company Overview 23 5.5.1 enmodes GmbH Pipeline Products & Ongoing Clinical Trials Overview 23 5.6 Haemair Ltd Company Overview 24 5.6.1 Haemair Ltd Pipeline Products & Ongoing Clinical Trials Overview 24 5.7 Liberate Medical, LLC Company Overview 25 5.7.1 Liberate Medical, LLC Pipeline Products & Ongoing Clinical Trials Overview 25 5.8 Lung Biotechnology PBC Company Overview 26 5.8.1 Lung Biotechnology PBC Pipeline Products & Ongoing Clinical Trials Overview 26 5.9 McGowan Institute for Regenerative Medicine Company Overview 27 5.9.1 McGowan Institute for Regenerative Medicine Pipeline Products & Ongoing Clinical Trials Overview 27 5.10 MedArray Inc. Company Overview 29 5.10.1 MedArray Inc. Pipeline Products & Ongoing Clinical Trials Overview 29 5.11 Merit Medical Systems Inc Company Overview 30 5.11.1 Merit Medical Systems Inc Pipeline Products & Ongoing Clinical Trials Overview 30 5.12 Michigan Critical Care Consultants, Inc. Company Overview 32 5.12.1 Michigan Critical Care Consultants, Inc. Pipeline Products & Ongoing Clinical Trials Overview 32 5.13 Miromatrix Medical Inc Company Overview 33 5.13.1 Miromatrix Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 33 5.14 Pneumedicare Ltd. Company Overview 34 5.14.1 Pneumedicare Ltd. Pipeline Products & Ongoing Clinical Trials Overview 34 5.15 Rice University Company Overview 35 5.15.1 Rice University Pipeline Products & Ongoing Clinical Trials Overview 35 5.16 The Charles Stark Draper Laboratory Inc Company Overview 36 5.16.1 The Charles Stark Draper Laboratory Inc Pipeline Products & Ongoing Clinical Trials Overview 36 5.17 University of Arizona Company Overview 37 5.17.1 University of Arizona Pipeline Products & Ongoing Clinical Trials Overview 37 5.18 University of California Los Angeles Company Overview 38 5.18.1 University of California Los Angeles Pipeline Products & Ongoing Clinical Trials Overview 38 5.19 University of California San Francisco Company Overview 39 5.19.1 University of California San Francisco Pipeline Products & Ongoing Clinical Trials Overview 39 5.20 University of Kansas Company Overview 40 5.20.1 University of Kansas Pipeline Products & Ongoing Clinical Trials Overview 40 5.21 University of Michigan Company Overview 41 5.21.1 University of Michigan Pipeline Products & Ongoing Clinical Trials Overview 41 5.22 University of Pittsburgh Company Overview 42 5.22.1 University of Pittsburgh Pipeline Products & Ongoing Clinical Trials Overview 42 5.23 Xenios AG Company Overview 43 5.23.1 Xenios AG Pipeline Products & Ongoing Clinical Trials Overview 43 6 Respiratory Assist Devices- Recent Developments 45 6.1 Jan 02, 2018: Teleflex Completes Previously Announced CEO Transition 45 6.2 Nov 07, 2017: Inogen Announces Record Third Quarter 2017 Financial Results 45 6.3 Nov 02, 2017: Teleflex Reports Third Quarter 2017 Results 47 6.4 Sep 27, 2017: ALung Receives IDE Approval to Conduct VENT-AVOID Trial of the Hemolung RAS for the US Market 49 6.5 Sep 06, 2017: MGC Diagnostics Reports Fiscal 2017 Third Quarter Results 50 6.6 Sep 05, 2017: Soleno Therapeutics Announces CFO Transition 51 6.7 Aug 03, 2017: Teleflex Reports Second Quarter 2017 Results 52 6.8 Aug 03, 2017: Inogen Announces Record Second Quarter 2017 Financial Results 54 6.9 Aug 02, 2017: SAMHSA announces $6 million in grants to support the International President’s Emergency Plan for AIDS Relief Addiction Technology Transfer Centers 56 6.10 Jun 20, 2017: Holaira Announces Company Name Change to Nuvaira 56 6.11 Jun 02, 2017: Inogen Secures Additional Facility to Support Direct-to-Consumer Sales Growth 57 6.12 Jun 01, 2017: MGC Diagnostics Reports Fiscal 2017 Second Quarter Results 57 6.13 May 11, 2017: Capnia Provides Corporate Update and Reports First Quarter 2017 Financial Results 60 6.14 May 09, 2017: Inogen Announces First Quarter 2017 Financial Results 61 6.15 May 04, 2017: Teleflex Reports First Quarter 2017 Results 63 6.16 May 01, 2017: New Lung Support Technology Ras-Q Wins Emerging Medical Innovation Valuation Competition In Minneapolis 64 6.17 Apr 25, 2017: ALung Submits IDE Application to FDA Seeking Approval to Conduct Pivotal Study of the Hemolung RAS 65 6.18 Mar 15, 2017: Capnia Reports Fourth Quarter and Full Year 2016 Financial Results 66 6.19 Mar 07, 2017: MGC Diagnostics Reports Fiscal 2017 First Quarter Results 67 6.20 Feb 28, 2017: Inogen Announces Fourth Quarter and Full Year 2016 Financial Results and Updates 2017 Guidance 68 6.21 Feb 23, 2017: Teleflex Announces Benson Smith to Retire as Chief Executive Officer at End of 2017; Liam Kelly to Succeed Smith as Chief Executive Officer 71 6.22 Feb 23, 2017: Teleflex Reports Fourth Quarter and Full Year 2016 Results; Provides 2017 Guidance 71 7 Appendix 74 7.1 Methodology 74 7.2 About GlobalData 77 7.3 Contact Us 77 7.4 Disclaimer 77

1.1 List of Tables Table 1: Respiratory Assist Devices - Pipeline Products by Stage of Development 7 Table 2: Respiratory Assist Devices - Pipeline Products by Segment 8 Table 3: Respiratory Assist Devices - Pipeline Products by Territory 9 Table 4: Respiratory Assist Devices - Pipeline Products by Regulatory Path 10 Table 5: Respiratory Assist Devices - Pipeline Products by Estimated Approval Date 11 Table 6: Respiratory Assist Devices - Ongoing Clinical Trials 12 Table 7: Respiratory Assist Devices Companies - Pipeline Products by Stage of Development 13 Table 8: Respiratory Assist Devices - Pipeline Products by Stage of Development 14 Table 9: Advanced Respiratory Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview 15 Table 10: Pulmonary Assist Device - Product Status 15 Table 11: Pulmonary Assist Device - Product Description 15 Table 12: ALung Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 16 Table 13: Hattler Catheter - Product Status 16 Table 14: Hattler Catheter - Product Description 16 Table 15: Hemolung RAS - Product Status 17 Table 16: Hemolung RAS - Product Description 17 Table 17: ALung Technologies Inc - Ongoing Clinical Trials Overview 18 Table 18: Hemolung RAS - A Prospective, Multi-center, Randomized, Controlled, Pivotal Trial to Validate the Safety and Efficacy of the Hemolung Respiratory Assist System for COPD Patients Experiencing an Acute Exacerbation Requiring Ventilatory Support 19 Table 19: Hemolung RAS - Extra-corporeal CO2 Removal as an Adjunct to Non-Invasive Ventilation in Acute Severe Exacerbations of COPD 19 Table 20: Hemolung RAS - Physiological Study of Minimally Invasive Extracorporeal CO2 Removal in Exacerbations of COPD Requiring Invasive Mechanical Ventilation 19 Table 21: Hemolung RAS - Protective Ventilation with Veno-venous Lung Assist in Respiratory Failure 20 Table 22: Breethe, Inc. Pipeline Products & Ongoing Clinical Trials Overview 21 Table 23: OXY-1 - Product Status 21 Table 24: OXY-1 - Product Description 21 Table 25: Case Western Reserve University Pipeline Products & Ongoing Clinical Trials Overview 22 Table 26: Portable Artificial Lung - Product Status 22 Table 27: Portable Artificial Lung - Product Description 22 Table 28: enmodes GmbH Pipeline Products & Ongoing Clinical Trials Overview 23 Table 29: RAS-Q - Product Status 23 Table 30: RAS-Q - Product Description 23 Table 31: Haemair Ltd Pipeline Products & Ongoing Clinical Trials Overview 24 Table 32: Portable Artificial Lung - Product Status 24 Table 33: Portable Artificial Lung - Product Description 24 Table 34: Liberate Medical, LLC Pipeline Products & Ongoing Clinical Trials Overview 25 Table 35: VentFree - Product Status 25 Table 36: VentFree - Product Description 25 Table 37: Lung Biotechnology PBC Pipeline Products & Ongoing Clinical Trials Overview 26 Table 38: Implantable Artificial Lung - Product Status 26 Table 39: Implantable Artificial Lung - Product Description 26 Table 40: McGowan Institute for Regenerative Medicine Pipeline Products & Ongoing Clinical Trials Overview 27 Table 41: Biohybrid Artificial Lung - Product Status 27 Table 42: Biohybrid Artificial Lung - Product Description 27 Table 43: Chronic Artificial Lung - Product Status 28 Table 44: Chronic Artificial Lung - Product Description 28 Table 45: Impeller Percutaneous Respiratory Assist Catheter (iPRAC) - Product Status 28 Table 46: Impeller Percutaneous Respiratory Assist Catheter (iPRAC) - Product Description 28 Table 47: MedArray Inc. Pipeline Products & Ongoing Clinical Trials Overview 29 Table 48: Artificial Lung Fiber - Product Status 29 Table 49: Artificial Lung Fiber - Product Description 29 Table 50: Merit Medical Systems Inc Pipeline Products & Ongoing Clinical Trials Overview 30 Table 51: Elation Pulmonary Balloon Dilation Catheter - Product Status 30 Table 52: Elation Pulmonary Balloon Dilation Catheter - Product Description 31 Table 53: Michigan Critical Care Consultants, Inc. Pipeline Products & Ongoing Clinical Trials Overview 32 Table 54: BioLung - Product Status 32 Table 55: BioLung - Product Description 32 Table 56: Miromatrix Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 33 Table 57: Miromatrix Artificial Lung - Product Status 33 Table 58: Miromatrix Artificial Lung - Product Description 33 Table 59: Pneumedicare Ltd. Pipeline Products & Ongoing Clinical Trials Overview 34 Table 60: Pneumonitor - Product Status 34 Table 61: Pneumonitor - Product Description 34 Table 62: Rice University Pipeline Products & Ongoing Clinical Trials Overview 35 Table 63: Respiratory Assist Device - Product Status 35 Table 64: Respiratory Assist Device - Product Description 35 Table 65: The Charles Stark Draper Laboratory Inc Pipeline Products & Ongoing Clinical Trials Overview 36 Table 66: Silicone-Based Microfluidic Artificial Lung - Product Status 36 Table 67: Silicone-Based Microfluidic Artificial Lung - Product Description 36 Table 68: University of Arizona Pipeline Products & Ongoing Clinical Trials Overview 37 Table 69: HeCOS - Product Status 37 Table 70: HeCOS - Product Description 37 Table 71: University of California Los Angeles Pipeline Products & Ongoing Clinical Trials Overview 38 Table 72: Percutaneous Catheter for Lung Assist Device - Product Status 38 Table 73: Percutaneous Catheter for Lung Assist Device - Product Description 38 Table 74: University of California San Francisco Pipeline Products & Ongoing Clinical Trials Overview 39 Table 75: Neonatal ECMO Device - Product Status 39 Table 76: Neonatal ECMO Device - Product Description 39 Table 77: University of Kansas Pipeline Products & Ongoing Clinical Trials Overview 40 Table 78: VestibuGLIDE System - Product Status 40 Table 79: VestibuGLIDE System - Product Description 40 Table 80: University of Michigan Pipeline Products & Ongoing Clinical Trials Overview 41 Table 81: M-Lung - Product Status 41 Table 82: M-Lung - Product Description 41 Table 83: University of Pittsburgh Pipeline Products & Ongoing Clinical Trials Overview 42 Table 84: Paracorporeal Ambulatory Assist Lung - Product Status 42 Table 85: Paracorporeal Ambulatory Assist Lung - Product Description 42 Table 86: Xenios AG Pipeline Products & Ongoing Clinical Trials Overview 43 Table 87: i-lung - Product Status 43 Table 88: i-lung - Product Description 43 Table 89: Xtralung - Product Status 44 Table 90: Xtralung - Product Description 44 Table 91: Glossary 761.2 List of Figures Figure 1: Respiratory Assist Devices - Pipeline Products by Stage of Development 7 Figure 2: Respiratory Assist Devices - Pipeline Products by Segment 8 Figure 3: Respiratory Assist Devices - Pipeline Products by Territory 9 Figure 4: Respiratory Assist Devices - Pipeline Products by Regulatory Path 10 Figure 5: Respiratory Assist Devices - Pipeline Products by Estimated Approval Date 11 Figure 6: Respiratory Assist Devices - Ongoing Clinical Trials 12

Advanced Respiratory Technologies LLC ALung Technologies Inc Breethe, Inc. Case Western Reserve University enmodes GmbH Haemair Ltd Liberate Medical, LLC Lung Biotechnology PBC McGowan Institute for Regenerative Medicine MedArray Inc. Merit Medical Systems Inc Michigan Critical Care Consultants, Inc. Miromatrix Medical Inc Pneumedicare Ltd. Rice University The Charles Stark Draper Laboratory Inc University of Arizona University of California Los Angeles University of California San Francisco University of Kansas University of Michigan University of Pittsburgh Xenios AG