Table of Contents PART 01: Executive summary PART 02: Scope of the report PART 03: Research Methodology PART 04: Introduction • Key market highlights PART 05: Market landscape • Market overview • Five forces analysis PART 06: Market segmentation by products • Braces and supporting systems • Accessories • Orthobiologics PART 07: Market segmentation by procedures • Joint replacement and fracture • Nerve diseases and soft tissue injuries PART 08: Market segmentation by end user • Hospitals and clinics • ASCs PART 09: Geographical segmentation • Lower extremities market in Americas • Lower extremities market in EMEA • Lower extremities market in APAC PART 10: Decision framework PART 11: Drivers and challenges • Market drivers • Impact of drivers on key customer segments • Market challenges • Impact of challenges on key customer segments PART 12: Market trends • Growing popularity of MI procedures • Technological advances • Increase in orthopedic outsourcing PART 13: Vendor landscape • Competitive landscape PART 14: Key vendor analysis • DePuy Synthes • Stryker • Zimmer Biomet • Other prominent vendors PART 15: Appendix • List of abbreviations List of Exhibits Exhibit 01: Overview of global orthopedic devices market and global lower extremities market 2016 Exhibit 02: Market overview of lower extremities market 2016 and 2021 Exhibit 03: Global lower extremities market 2016-2021 ($ billions) Exhibit 04: Unmet needs and strategies obtained by the companies to increase market growth Exhibit 05: Market impact: M&A in lower extremities Exhibit 06: Five forces analysis Exhibit 07: Global lower extremities market by product 2016 and 2021 ($ billions) Exhibit 08: Market overview: Braces and supporting systems Exhibit 09: Global lower extremities braces and supporting systems market 2016-2021 ($ billions) Exhibit 10: M&A: Supporting systems Exhibit 11: Market overview: Accessories Exhibit 12: Global lower extremities accessories market 2016-2021 ($ billions) Exhibit 13: Global lower extremities orthobiologics market 2016-2021 ($ billions) Exhibit 14: Funding for orthobiologics development Exhibit 15: Global lower extremities market by procedures 2016 Exhibit 16: Market overview: Joint replacement Exhibit 17: Global lower extremities market by end-users 2016 Exhibit 18: Lower extremities market: Strategies for companies and hospitals and clinics Exhibit 19: Global lower extremities market segmentation by geography 2016 and 2021 ($ billions) Exhibit 20: Market overview: Lower extremities market Exhibit 21: Percentage of obese population in Americas above 15 years old in 2013 Exhibit 22: Lower extremities market in Americas 2016-2021 ($ billions) Exhibit 23: Lower extremities market in Americas: Market analysis in various countries Exhibit 24: Market overview: Lower extremities market in US Exhibit 25: Market overview: Lower extremities market in EMEA Exhibit 26: Factors leading to primary knee replacement surgeries in UK 2015 Exhibit 27: Lower extremities market in EMEA 2016-2021 ($ billions) Exhibit 28: Lower extremities market in EMEA: Market analysis in various countries Exhibit 29: Market overview: Lower extremities market in UK Exhibit 30: Market overview: Lower extremities market in APAC Exhibit 31: Lower extremities market in APAC 2016-2021 ($ billions) Exhibit 32: Lower extremities market in APAC: Market analysis in various countries Exhibit 33: New technological product launches in key markets Exhibit 34: M&A Exhibit 35: Number of road injuries reported in UK 2015 Exhibit 36: Revision hip replacement procedures in UK 2014 and 2015 Exhibit 37: Knee procedures in Australia 2013-2016 Exhibit 38: Impact of drivers Exhibit 39: Average treatment cost of hip fractures Exhibit 40: Average procedure cost of hip fracture procedure Exhibit 41: Types of lower extremity orthopedic procedure and its complications Exhibit 42: Impact of challenges Exhibit 43: Competitive structure analysis of global lower extremities market 2016 Exhibit 44: Competitive landscape analysis of global lower extremities market 2016 Exhibit 45: Strategic recommendation for vendors in the global lower extremities market Exhibit 46: DePuy Synthes: Key highlights Exhibit 47: DePuy Synthes: Strength assessment Exhibit 48: DePuy Synthes: Strategy assessment Exhibit 49: DePuy Synthes: Opportunity assessment Exhibit 50: Stryker: Key highlights Exhibit 51: Stryker: Strength assessment Exhibit 52: Stryker: Strategy assessment Exhibit 53: Stryker: Opportunity assessment Exhibit 54: Zimmer Biomet: Key highlights Exhibit 55: Zimmer Biomet: Strength assessment Exhibit 56: Zimmer Biomet: Strategy assessment Exhibit 57: Zimmer Biomet: Opportunity assessment Exhibit 58: Global lower extremities market: Other prominent vendors

DePuy Synthes, Stryker, Zimmer Biomet, Active Implants, Acumed, Arthrex, Avitus Orthopaedics, Biotech Limb and Brace, Bioventus, Bone Therapeutics, Bone Biologics, Ceramisys, ConforMIS, CONMED, CollPlant, DJO Global, Evolutis, Exactech, FH Orthopedics, Graftys, ICONACY Orthopedic Implants, Integra LifeSciences, implantcast, Isto Biologics , Lima Corporate, Medtronic, Merete Group, Össur, OsteoMed, Orthofix, Orthogem, Promedics Orthopaedic, Regenexx,, RTI Surgical, Sigma Graft, Silver Bullet Therapeutics, Skye Biologics, Smith & Nephew, Stanmore Implants Worldwide, Surgical Appliance Industries, Wright Medical Group, and Xtant Medical.