Table of Contents PART 01: Executive summary • Highlights PART 02: Scope of the report • Market overview • Assumptions • Top-vendor offerings PART 03: Market research methodology • Research methodology • Economic indicators PART 04: Introduction • Key market highlights • A glance at parent market: Artificial organs PART 05: An overview of pancreas and diabetes • Pancreas • Diabetes • Insulin overview PART 06: Need for better systems in the management of diabetes PART 07: Artificial pancreas device system • Technology landscape PART 08: Initiatives for the development of APDS • Juvenile Diabetes Research Foundation (JDRF) initiative — 2006 • European Commission’s AP@home project — 2010 • Centre for bio-inspired technology — Bionic pancreas • Harvard University — 2014 PART 09: FDA’s role in fostering the development of APDS • Rapid response to preliminary study plans • Interactive review of investigational device exemption study plans • Guidance and standards for researchers and industry PART 10: Reimbursement scenario • Australia • Germany • UK • US PART 11: Key clinical trials PART 12: Market landscape • Market overview • Five forces analysis PART 13: Market segmentation by categories • TSDS • NTSDS • CTRS • CTTS PART 14: Geographical segmentation • APDS market in Americas • APDS market in EMEA • APDS market in APAC PART 15: Market drivers • Growing technological integration fuelling the market growth • Increasing initiatives of research organizations fostering innovation in the market • Increasing prevalence of diabetes fuelling the need for effective devices PART 16: Impact of drivers PART 17: Market challenges • Lack of smart control algorithms affecting the adoption rate of existing APDS • Low penetration rates affecting the market growth • Lab-grown pancreatic cell transplant as a potential treatment alternative hindering the growth prospects PART 18: Impact of drivers and challenges PART 19: Market trends • Increasing focus on closed loop systems • Growing demand for remote monitoring applications • Focus of new entrants on the development of novel APDS PART 20: Vendor landscape • Competitive scenario PART 21: Key vendor analysis • Medtronic • Johnson & Johnson • Insulet • Tandem Diabetes Care • Roche • Other prominent vendors PART 22: Appendix • List of abbreviations PART 23: Explore Technavio List of Exhibits Exhibit 01: Product offerings Exhibit 02: Key segments in artificial organ market Exhibit 03: Diagnosis of diabetes by blood sugar test Exhibit 04: Diagnosis of diabetes by glycated hemoglobin test Exhibit 05: Treatment algorithm for type 2 diabetes Exhibit 06: Factors that fuelled the need for APDS Exhibit 07: Technology involved in the functioning of APDS Exhibit 08: Barriers in CGM Exhibit 09: Barriers in hormonal pumps Exhibit 10: Key findings of researchers related to algorithms till date Exhibit 11: Key clinical trials Exhibit 12: Global APDS market snapshot Exhibit 13: Development path of APDS Exhibit 14: Global APDS market 2015-2020 ($ millions) Exhibit 15: Key factors driving the demand for closed loop systems Exhibit 16: Scenario analysis of global APDS market Exhibit 17: Five forces analysis Exhibit 18: Pipeline products Exhibit 19: Key pipeline products Exhibit 20: Scenario analysis of key segments in global APDS market Exhibit 21: Segmentation of global APDS market based on geography 2015 and 2020 Exhibit 22: APDS market revenue by geography 2015-2020 ($ millions) Exhibit 23: Market scenario in Americas Exhibit 24: APDS market in the Americas ($ millions) Exhibit 25: Market scenario in EMEA Exhibit 26: APDS market in EMEA ($ millions) Exhibit 27: Market scenario in EMEA Exhibit 28: APDS market in APAC ($ millions) Exhibit 29: Key technological integrations Exhibit 30: Key initiatives of research organizations Exhibit 31: Incidence and prevalence for diabetes in the US Exhibit 32: Traditional systems vs APDS Exhibit 33: Impact of drivers Exhibit 34: Forcefield analysis of drivers and challenges Exhibit 35: Impact of drivers and challenges Exhibit 36: Key trends in the development of closed loop systems Exhibit 37: Key products under development for remote monitoring applications Exhibit 38: New entrants and their expected product launches Exhibit 39: Competitive structure analysis of global APDS market 2015 Exhibit 40: Competitive analysis of global APDS market Exhibit 41: Market share analysis 2015 Exhibit 42: Market penetration of various APDS manufacturers in global (2015) Exhibit 43: Timeline chart representing the development of APDS Exhibit 44: Strategic success factors of companies in global APDS market Exhibit 45: Key highlights Exhibit 46: Strength assessment Exhibit 47: Strategy assessment Exhibit 48: Opportunity assessment Exhibit 49: Key highlights Exhibit 50: Strength assessment Exhibit 51: Strategy assessment Exhibit 52: Opportunity assessment Exhibit 53: Key highlights Exhibit 54: Strength assessment Exhibit 55: Strategy assessment Exhibit 56: Opportunity assessment Exhibit 57: Key highlights Exhibit 58: Strength assessment Exhibit 59: Strategy assessment Exhibit 60: Opportunity assessment Exhibit 61: Key highlights Exhibit 62: Strength assessment Exhibit 63: Strategy assessment Exhibit 64: Opportunity assessment

Medtronic, Johnson & Johnson, Insulet, Tandem Diabetes Care, Roche, Beta Bionics, Bigfoot Biomedical, Cellnovo, Dexcom, Dose Safety, DreaMed Diabetes, Inreda Diabetic, Type Zero Technologies.