PART 01: Executive summary • Highlights PART 02: Scope of the report • Market overview • Top-vendor offerings PART 03: Market research methodology • Research methodology • Economic indicators PART 04: Introduction • Key market highlights PART 05: Spine biologics: An overview • Clinical need for biologics in spine surgeries • Funding in spine biologics • Spine biologic products under clinical trials PART 06: Market landscape • Market overview • Market size and forecast • Five forces analysis PART 07: Market segmentation by product • Allograft • Stem cells • BMP • DBM • Synthetic bone grafts PART 08: Global spine biologics market by allograft • Market size and forecast PART 09: Global spine biologics market by stem cells • Market overview • Market size and forecast PART 10: Global spine biologics market by BMP • Market overview PART 11: Global spine biologics market by DBM • Market overview • Market size and forecast PART 12: Global spine biologics market by synthetic bone grafts • Market overview PART 13: Geographical segmentation • Spine biologics market in Americas • Spine biologics market in EMEA • Spine biologics market in APAC PART 14: Key leading countries • US • Japan • Germany PART 15: Market drivers • Increased incidence of spinal disorders • Growing popularity of MI spinal and robot-assisted surgeries • Rise in strategic partnerships for marketing • Increase in older population PART 16: Impact of drivers PART 17: Market challenges • Complications associated with spine implants in surgeries • Stringent regulatory and reimbursement policies • High cost of spinal fusion surgery • Intense competition • Poor performance of bone graft substitute PART 18: Impact of drivers and challenges PART 19: Market trends • Advances in technology • Rise in popularity of physician-owned ASCs • Emerging MI sacroiliac joint fusion technique • Product development in collaboration with research institutes • Increase in M&A PART 20: Vendor landscape • Competitive scenario • Market share analysis • Medtronic • Johnson & Johnson • Stryker • NuVasive • Zimmer Biomet • SeaSpine • Other prominent vendors PART 21: Appendix • List of abbreviations PART 22: Explore Technavio List of Exhibits Exhibit 01: Product offerings Exhibit 02: Spine fusion techniques Exhibit 03: Funding for development of spine biologics Exhibit 04: List of spine biologic products under clinical trials Exhibit 05: Spine market model 2015 Exhibit 06: Global spine biologics market 2015-2020 ($ billions) Exhibit 07: Five forces analysis Exhibit 08: Segmentation of global spine biologics market by product type Exhibit 09: Global spine biologics market segmentation by product type 2015 Exhibit 10: Global spine biologics market by allografts 2015-2020 ($ millions) Exhibit 11: Global spine biologics market by stem cells 2015-2020 ($ millions) Exhibit 12: Global spine biologics market by BMP 2015-2020 ($ millions) Exhibit 13: Global spine biologics market by DBM 2015-2020 ($ millions) Exhibit 14: Global spine biologics market by synthetic bone grafts 2015-2020 ($ millions) Exhibit 15: Segmentation of global spine biologics market by product type 2015-2020 ($ millions) Exhibit 16: Segmentation of global spine biologics market by product type 2015-2020 (%) Exhibit 17: Global spine biologics market by geography 2015 Exhibit 18: Global spine biologics market by geography 2020 Exhibit 19: Spine biologics market in Americas 2015-2020 ($ billions) Exhibit 20: Spine biologics market in EMEA 2015-2020 ($ millions) Exhibit 21: Spine biologics market in APAC 2015-2020 ($ millions) Exhibit 22: Global spine biologics market by geography 2015-2020 ($ millions) Exhibit 23: Global spine biologics market by geography 2015-2020 Exhibit 24: Population aged 60 years and above: World, developed, and developing regions 1950-2050 (millions) Exhibit 25: Impact of drivers Exhibit 26: Comparison of the cost of spine surgeries 2015 Exhibit 27: Impact of drivers and challenges Exhibit 28: Ranking of top six vendors 2015 Exhibit 29: Market share of vendors 2015 Exhibit 30: Collaboration between vendors and universities or organizations Exhibit 31: Medtronic: Product portfolio Exhibit 32: Medtronic: Restorative Therapies group by revenue 2013-2015 ($ billions) Exhibit 33: Medtronic: Key takeaways Exhibit 34: Johnson & Johnson: Product portfolio Exhibit 35: Johnson & Johnson: Key takeaways Exhibit 36: Stryker: Product portfolio Exhibit 37: Stryker: Orthopedics segment by revenue 2013-2015 ($ billions) Exhibit 38: Stryker: Key takeaways Exhibit 39: NuVasive: Product portfolio Exhibit 40: NuVasive: Biologics segment by revenue 2013-2015 ($ millions) Exhibit 41: NuVasive: Key takeaways Exhibit 42: Zimmer Biomet: Product portfolio Exhibit 43: Zimmer Biomet: Key takeaways Exhibit 44: SeaSpine: Product portfolio Exhibit 45: SeaSpine: Orthopedics segment by revenue 2013-2015 ($ millions) Exhibit 46: SeaSpine: Key takeaways Exhibit 47: Other prominent vendors

Medtronic, Johnson & Johnson, Stryker, NuVasive, Zimmer Biomet, SeaSpine, Alphatec Spine, AMEDICA, Anika Therapeutics, Arthrex, Baxter, Berkeley Advanced Biomaterial, Biomimetic Therapeutics, Globus Medical, Integra Life Sciences, ISTO Technologies, K2M, LDR, Orthofix International, RTI Surgical, Xtant Medical.